RNA
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A man that police caught taking 217 doses of COVID vaccine has offered himself up to researchers for a study looking into what happens to the immune system after so many doses. The results offer surprising insight into these new mRNA vaccines.
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Our bodies are home to trillions of microbes, including bacteria, viruses, fungi, and a whole host of others. Now, Stanford scientists have discovered an entirely new class of biological entities inside us, which they’ve ominously named “Obelisks.”
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Researchers have created a ‘two-headed’ drug that prevents the production of the toxic protein linked to Parkinson’s disease before destroying the RNA machinery that makes it. The drug may be a way of slowing or even stopping the disease’s progression.
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Moderna has announced results of a Phase 2b trial of its mRNA treatment for skin cancer. When paired with immunotherapy, the treatment significantly reduced risks of recurrence, metastasis and death, paving the way for trials against other cancers.
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Researchers have discovered that mice possess a natural form of gene therapy, a non-coding RNA that can sidestep genetic mutations. They were able to engineer a programmable version that might be used to treat genetic diseases in humans.
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Researchers discovered that a modification to the synthetic mRNA used in therapeutics can cause the cell’s machinery to misread its instructions, leading to unintended immune responses. Importantly, they’ve also discovered a solution to the problem.
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Researchers have conducted the first human trials of a new drug, lepodisiran, and found that a single injection reduced lipoprotein(a) – a ‘bad’ cholesterol with a genetic basis and no available treatments – to undetectable levels for almost a year.
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Researchers investigating the genetics underlying the airway inflammation seen in severe asthma have, for the first time, discovered that proteins that bind to RNA are dysregulated, driving changes in gene expression in cells that line the airways.
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Researchers have found that remnants left over after a cell divides contain RNA that, when taken up by other cells, can spread cancer’s genetic blueprint. The finding opens the door to harnessing this mechanism as a way of treating cancer.
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The 2023 Nobel Prize in Physiology or Medicine has been awarded to biochemist Katalin Karikó and immunologist Drew Weissman for discoveries that enabled the development of mRNA vaccines against COVID-19.
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Scientists have successfully extracted RNA from an extinct species for the first time. This was achieved in the thylacine, a species of carnivorous marsupial that roamed Australia until a century ago – and may again one day, if current plans bear fruit.
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Researchers have gained new insights into largely overlooked circular RNAs in brain cells and the crucial role they play in diseases like Alzheimer’s and Parkinson’s, opening the door to developing diagnostic tests and treatments for them.
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