Google and parent company Alphabet lost an appeal Wednesday against a landmark €4.3 billion antitrust fine in what lawyers described as a triumph for the aggressive antitrust enforcement approach pursued by competition czar Margrethe Vestager.

The decision from the General Court centered on a 2018 fine imposed by Brussels officials on the Mountain View, California-headquartered company for allegedly placing anti-competitive restrictions on manufacturers of mobile devices and mobile network operators to protect and bolster the dominant position of its search engine, Google Search, and the revenue from search advertisements. The fine was the largest ever given by a competition authority in Europe.